Validation of a 3-h Sampling Interval to Assess Variability in Cytochrome P450 3A Phenotype and the Impact of Induction and Mechanism-Based Inhibition Using Midazolam as a Probe Substrate

Validation of a 3-h Sampling Interval to Assess Variability in Cytochrome P450 3A Phenotype and the Impact of Induction and Mechanism-Based Inhibition Using Midazolam as a Probe Substrate

Background: Drug probe phenotyping is used extensively in academic and industry research to evaluate cytochrome P450 (CYP) phenotype in order to account for sources of between- and within- subject variability in metabolic clearance. In terms of application, CYP3A is the most important drug metaboliz...

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Main Authors: Madelé van Dyk (Author), Asha J. Kapetas (Author), Ashley M. Hopkins (Author), A. David Rodrigues (Author), Manoli Vourvahis (Author), Michael J. Sorich (Author), Andrew Rowland (Author)
Format: Book
Published: Frontiers Media S.A., 2019-09-01T00:00:00Z.
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3rd Floor Main Library

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