Validation of a 3-h Sampling Interval to Assess Variability in Cytochrome P450 3A Phenotype and the Impact of Induction and Mechanism-Based Inhibition Using Midazolam as a Probe Substrate

• मुख्य लेखकों: Madelé van Dyk (लेखक), Asha J. Kapetas (लेखक), Ashley M. Hopkins (लेखक), A. David Rodrigues (लेखक), Manoli Vourvahis (लेखक), Michael J. Sorich (लेखक), Andrew Rowland (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2019-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Background: Drug probe phenotyping is used extensively in academic and industry research to evaluate cytochrome P450 (CYP) phenotype in order to account for sources of between- and within- subject variability in metabolic clearance. In terms of application, CYP3A is the most important drug metaboliz...