Leukemia development initiated by deletion of RBP-J: mouse strain, deletion efficiency and cell of origin

• Asıl Yazarlar: Brian Chipman Belyea (Yazar), Fang Xu (Yazar), Maria Luisa Soledad Sequeira-Lopez (Yazar), Roberto Ariel Gomez (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: The Company of Biologists, 2018-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Conditional deletion of RBP-J, the major transcriptional effector of Notch signaling, specifically within renin-expressing cells leads to the development of B-cell leukemia. However, the influence of contributing factors such as mouse strain, cell of origin and Cre recombinase copy number are unknow...