Downregulation of hepatic lipopolysaccharide binding protein improves lipogenesis-induced liver lipid accumulation

• Main Authors: Jessica Latorre (Author), Ramon Díaz-Trelles (Author), Ferran Comas (Author), Aleix Gavaldà-Navarro (Author), Edward Milbank (Author), Nathalia Dragano (Author), Samantha Morón-Ros (Author), Rajesh Mukthavaram (Author), Francisco Ortega (Author), Anna Castells-Nobau (Author), Núria Oliveras-Cañellas (Author), Wifredo Ricart (Author), Priya P. Karmali (Author), Kiyoshi Tachikawa (Author), Pad Chivukula (Author), Francesc Villarroya (Author), Miguel López (Author), Marta Giralt (Author), José Manuel Fernández-Real (Author), José María Moreno-Navarrete (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Circulating lipopolysaccharide-binding protein (LBP) is increased in individuals with liver steatosis. We aimed to evaluate the possible impact of liver LBP downregulation using lipid nanoparticle-containing chemically modified LBP small interfering RNA (siRNA) (LNP-Lbp UNA-siRNA) on the development...