Noggin depletion in adipocytes promotes obesity in mice

• Main Authors: Ana M. Blázquez-Medela (Author), Medet Jumabay (Author), Prashant Rajbhandari (Author), Tamer Sallam (Author), Yina Guo (Author), Jiayi Yao (Author), Laurent Vergnes (Author), Karen Reue (Author), Li Zhang (Author), Yucheng Yao (Author), Alan M. Fogelman (Author), Peter Tontonoz (Author), Aldons J. Lusis (Author), Xiuju Wu (Author), Kristina I. Boström (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Obesity has increased to pandemic levels and enhanced understanding of adipose regulation is required for new treatment strategies. Although bone morphogenetic proteins (BMPs) influence adipogenesis, the effect of BMP antagonists such as Noggin is largely unknown. The aim of the study was...