Potential Applications of NRF2 Modulators in Cancer Therapy

• Main Authors: Emiliano Panieri (Author), Aleksandra Buha (Author), Pelin Telkoparan-Akillilar (Author), Dilek Cevik (Author), Demetrios Kouretas (Author), Aristidis Veskoukis (Author), Zoi Skaperda (Author), Aristidis Tsatsakis (Author), David Wallace (Author), Sibel Suzen (Author), Luciano Saso (Author)
• Format: Book
• Published: MDPI AG, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The nuclear factor erythroid 2-related factor 2 (NRF2)−Kelch-like ECH-associated protein 1 (KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from oxidative, electrophilic, and xenobiotic stress. By controlling the transactivation of over 500 cytoprotective...