Mixed and non-competitive enzyme inhibition: underlying mechanisms and mechanistic irrelevance of the formal two-site model

• Kaituhi matua: Alessandro Pesaresi (Author)
• Hōputu: Pukapuka
• I whakaputaina: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

The formal mechanism of linear mixed and non-competitive enzyme inhibition implies the binding of inhibitors to both the active site of the free enzyme in competition with the substrate, and to an allosteric site on the enzyme-substrate complex. However, it is evident from a review of the scientific...