Aryl Urea Based Scaffolds for Multitarget Drug Discovery in Anticancer Immunotherapies

• Main Authors: Celia Martín-Beltrán (Author), Raquel Gil-Edo (Author), Germán Hernández-Ribelles (Author), Raül Agut (Author), Pilar Marí-Mezquita (Author), Miguel Carda (Author), Eva Falomir (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Twenty-one styryl and phenethyl aryl ureas have been synthetized and biologically evaluated as multitarget inhibitors of Vascular endothelial growth factor receptor-2 VEGFR-2 and programmed death-ligand-1 (PD-L1) proteins in order to overcome resistance phenomena offered by cancer. The antiprolifera...