M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b

• Main Authors: Chiara Parisi (Author), Giulia Napoli (Author), Pablo Pelegrin (Author), Cinzia Volonté (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Amyotrophic lateral sclerosis (ALS) is a most frequently occurring and severe form of motor neuron disease, causing death within 3-5 years from diagnosis and with a worldwide incidence of about 2 per 100,000 person-years. Mutations in over twenty genes associated with familial forms of ALS have prov...