Vasorelaxing Action of the Kynurenine Metabolite, Xanthurenic Acid: The Missing Link in Endotoxin-Induced Hypotension?

• Main Authors: Carmine Vecchione (Author), Francesco Fazio (Author), Albino Carrizzo (Author), Luana Lionetto (Author), Antonio Damato (Author), Luca Capocci (Author), Mariateresa Ambrosio (Author), Giuseppe Battaglia (Author), Valeria Bruno (Author), Michele Madonna (Author), Maurizio Simmaco (Author), Ferdinando Nicoletti (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The kynurenine pathway of tryptophan metabolism is activated by pro-inflammatory cytokines. L-kynurenine, an upstream metabolite of the pathway, acts as a putative endothelium-derived relaxing factor, and has been hypothesized to play a causative role in the pathophysiology of inflammation-induced h...