Mechanistic Insight into the Regulation of Lipoxygenase-Driven Lipid Peroxidation Events in Human Spermatozoa and Their Impact on Male Fertility

• Main Authors: Jessica L. H. Walters (Author), Amanda L. Anderson (Author), Sarah J. Martins da Silva (Author), R. John Aitken (Author), Geoffry N. De Iuliis (Author), Jessie M. Sutherland (Author), Brett Nixon (Author), Elizabeth G. Bromfield (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A prevalent cause of sperm dysfunction in male infertility patients is the overproduction of reactive oxygen species, an attendant increase in lipid peroxidation and the production of cytotoxic reactive carbonyl species such as 4-hydroxynonenal. Our previous studies have implicated arachidonate 15-l...