Ligand-based virtual-screening identified a novel CFTR ligand which improves the defective cell surface expression of misfolded ABC transporters

Cystic fibrosis (CF) is a monogenetic disease caused by the mutation of CFTR, a cAMP-regulated Cl− channel expressing at the apical plasma membrane (PM) of epithelia. ∆F508-CFTR, the most common mutant in CF, fails to reach the PM due to its misfolding and premature degradation at the endoplasmic re...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Shogo Taniguchi (Auteur), Francois Berenger (Auteur), Yukako Doi (Auteur), Ayana Mimura (Auteur), Yoshihiro Yamanishi (Auteur), Tsukasa Okiyoneda (Auteur)
Formaat: Boek
Gepubliceerd in: Frontiers Media S.A., 2024-04-01T00:00:00Z.
Onderwerpen:
Online toegang:Connect to this object online.
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Internet

Connect to this object online.

3rd Floor Main Library

Exemplaargegevens van 3rd Floor Main Library
Plaatsingsnummer: A1234.567
Kopie 1 Beschikbaar