A cabazitaxel liposome for increased solubility, enhanced antitumor effect and reduced systemic toxicity

• Main Authors: Xiaoyi Yin (Author), Lihua Luo (Author), Wei Li (Author), Jie Yang (Author), Chunqi Zhu (Author), Mengshi Jiang (Author), Bing qin (Author), Xiaoling Yuan (Author), Hang Yin (Author), Yichao Lu (Author), Yongzhong Du (Author), Dawei Chen (Author), Jian You (Author)
• Format: Book
• Published: Elsevier, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The potential side effects of cabazitaxel (CBZ) in the field of cancer treatment have become a great limitation to its further clinical application. Liposomal delivery is a well-established approach to increase the therapeutic index of hydrophobic drugs. In this study, a PEG-modified liposome was de...