Navitoclax Enhances the Therapeutic Effects of PLK1 Targeting on Lung Cancer Cells in 2D and 3D Culture Systems

• Váldodahkkit: Bárbara Pinto (Dahkki), Pedro Novais (Dahkki), Ana C. Henriques (Dahkki), Juliana Carvalho-Tavares (Dahkki), Patrícia M. A. Silva (Dahkki), Hassan Bousbaa (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2022-06-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

The efficacy of antimitotics is limited by slippage, whereby treated cells arrested in mitosis exit mitosis without cell division and, eventually, escape apoptosis, constituting a serious resistance mechanism to antimitotics. Strategies to overcome slippage should potentiate the cancer cell killing...