Navitoclax Enhances the Therapeutic Effects of PLK1 Targeting on Lung Cancer Cells in 2D and 3D Culture Systems

Navitoclax Enhances the Therapeutic Effects of PLK1 Targeting on Lung Cancer Cells in 2D and 3D Culture Systems

The efficacy of antimitotics is limited by slippage, whereby treated cells arrested in mitosis exit mitosis without cell division and, eventually, escape apoptosis, constituting a serious resistance mechanism to antimitotics. Strategies to overcome slippage should potentiate the cancer cell killing...

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Bibliographic Details
Main Authors: Bárbara Pinto (Author), Pedro Novais (Author), Ana C. Henriques (Author), Juliana Carvalho-Tavares (Author), Patrícia M. A. Silva (Author), Hassan Bousbaa (Author)
Format: Book
Published: MDPI AG, 2022-06-01T00:00:00Z.
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