CPPs to the Test: Effects on Binding, Uptake and Biodistribution of a Tumor Targeting Nanobody

• Main Authors: Estel Collado Camps (Author), Sanne A. M. van Lith (Author), Cathelijne Frielink (Author), Jordi Lankhof (Author), Ingrid Dijkgraaf (Author), Martin Gotthardt (Author), Roland Brock (Author)
• Format: Bog
• Udgivet: MDPI AG, 2021-06-01T00:00:00Z.
• Fag: article
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Nanobodies are well-established targeting ligands for molecular imaging and therapy. Their short circulation time enables early imaging and reduces systemic radiation exposure. However, shorter circulation time leads to lower tracer accumulation in the target tissue. Cell-penetrating peptides (CPPs)...