Acacetin and Chrysin, Two Polyphenolic Compounds, Alleviate Telomeric Position Effect in Human Cells

• Main Authors: Amina Boussouar (Author), Caroline Barette (Author), Robert Nadon (Author), Adelaïde Saint-Léger (Author), Natacha Broucqsault (Author), Alexandre Ottaviani (Author), Arva Firozhoussen (Author), Yiming Lu (Author), Laurence Lafanechère (Author), Eric Gilson (Author), Frédérique Magdinier (Author), Jing Ye (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We took advantage of the ability of human telomeres to silence neighboring genes (telomere position effect or TPE) to design a high-throughput screening assay for drugs altering telomeres. We identified, for the first time, that two dietary flavones, acacetin and chrysin, are able to specifically al...