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Acacetin and Chrysin, Two Polyphenolic Compounds, Alleviate Telomeric Position Effect in Human Cells

We took advantage of the ability of human telomeres to silence neighboring genes (telomere position effect or TPE) to design a high-throughput screening assay for drugs altering telomeres. We identified, for the first time, that two dietary flavones, acacetin and chrysin, are able to specifically al...

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Main Authors: Amina Boussouar (Author), Caroline Barette (Author), Robert Nadon (Author), Adelaïde Saint-Léger (Author), Natacha Broucqsault (Author), Alexandre Ottaviani (Author), Arva Firozhoussen (Author), Yiming Lu (Author), Laurence Lafanechère (Author), Eric Gilson (Author), Frédérique Magdinier (Author), Jing Ye (Author)
Format: Book
Published: Elsevier, 2013-01-01T00:00:00Z.
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Summary:We took advantage of the ability of human telomeres to silence neighboring genes (telomere position effect or TPE) to design a high-throughput screening assay for drugs altering telomeres. We identified, for the first time, that two dietary flavones, acacetin and chrysin, are able to specifically alleviate TPE in human cells. We further investigated their influence on telomere integrity and showed that both drugs drastically deprotect telomeres against DNA damage response. However, telomere deprotection triggered by shelterin dysfunction does not affect TPE, indicating that acacetin and chrysin target several functions of telomeres. These results show that TPE-based screening assays represent valuable methods to discover new compounds targeting telomeres.
Item Description:2162-2531
10.1038/mtna.2013.42

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