Elevated serum polyclonal immunoglobulin free light chains in patients with severe asthma

• Main Authors: Umberto Basile (Author), Giuseppe Santini (Author), Cecilia Napodano (Author), Giuseppe Macis (Author), Krizia Pocino (Author), Francesca Gulli (Author), Mario Malerba (Author), Andrew Bush (Author), Ian M. Adcock (Author), Paolo Montuschi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Inflammation plays a pivotal role in the pathophysiology of asthma. Free light chains (FLC) can cause inflammation by mast cell antigen-activation. Serum immunoglobulin (Ig) FLC κ, but not λ, were shown elevated in adult males with asthma. We sought to investigate if serum Ig FLC concent...