Polaprezinc attenuates cyclophosphamide-induced cystitis and related bladder pain in mice

• Main Authors: Masahiro Murakami-Nakayama (Author), Maho Tsubota (Author), Saki Hiruma (Author), Fumiko Sekiguchi (Author), Kenji Matsuyama (Author), Takeshi Kimura (Author), Masahiro Moriyama (Author), Atsufumi Kawabata (Author)
• Format: Book
• Published: Elsevier, 2015-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cav3.2 T-type Ca2+ channels targeted by H2S, a gasotransmitter, participate in cyclophosphamide-induced cystitis and bladder pain. Given that zinc selectively inhibits Cav3.2 among T-channel isoforms and also exhibits antioxidant activity, we examined whether polaprezinc (zinc-l-carnosine), a medici...