GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells

GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells

Targeted delivery of antisense oligonucleotide (AON) drugs is a promising strategy to increase their concentration in the desired tissues and cell types while reducing access to other organs. Conjugation of AONs to N-acetylgalactosamine (GalNAc) has been shown to efficiently shift their biodistribut...

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Main Authors: Sabine Sewing (Author), Marcel Gubler (Author), Régine Gérard (Author), Blandine Avignon (Author), Yasmin Mueller (Author), Annamaria Braendli-Baiocco (Author), Marielle Odin (Author), Annie Moisan (Author)
Format: Book
Published: Elsevier, 2019-03-01T00:00:00Z.
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