GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells

• Auteurs principaux: Sabine Sewing (Auteur), Marcel Gubler (Auteur), Régine Gérard (Auteur), Blandine Avignon (Auteur), Yasmin Mueller (Auteur), Annamaria Braendli-Baiocco (Auteur), Marielle Odin (Auteur), Annie Moisan (Auteur)
• Format: Livre
• Publié: Elsevier, 2019-03-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Targeted delivery of antisense oligonucleotide (AON) drugs is a promising strategy to increase their concentration in the desired tissues and cell types while reducing access to other organs. Conjugation of AONs to N-acetylgalactosamine (GalNAc) has been shown to efficiently shift their biodistribut...