Surgical Debulking Modifies Notch Signaling and May Improve Vismodegib Effectiveness for Locally Advanced Basal Cell Carcinoma

• Main Authors: Natella Maglakelidze (Author), Samantha L. Gettle (Author), Amy L. Longenecker (Author), Allison T. Vidimos (Author), Elizabeth M. Billingsley (Author), Ryan P. Hobbs (Author), Charlene Lam (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Smoothened inhibitors, such as vismodegib, exhibit remarkable success in treating patients with locally advanced basal cell carcinoma (LaBCC). Yet, vismodegib efficacy is hindered by notable side effects, which often lead to treatment discontinuation and subsequent relapse in patients with LaBCC. Pr...