Properly Substituted Benzimidazoles as a New Promising Class of Nicotinate Phosphoribosyltransferase (NAPRT) Modulators

• Main Authors: Cecilia Baldassarri (Author), Gianfabio Giorgioni (Author), Alessandro Piergentili (Author), Wilma Quaglia (Author), Stefano Fontana (Author), Valerio Mammoli (Author), Gabriele Minazzato (Author), Elisa Marangoni (Author), Massimiliano Gasparrini (Author), Leonardo Sorci (Author), Nadia Raffaelli (Author), Loredana Cappellacci (Author), Riccardo Petrelli (Author), Fabio Del Bello (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The prevention of nicotinamide adenine dinucleotide (NAD) biosynthesis is considered an attractive therapeutic approach against cancer, considering that tumor cells are characterized by an increased need for NAD to fuel their reprogrammed metabolism. On the other hand, the decline of NAD is a hallma...