Synthesis and biological evaluation of novel 8-substituted quinoline-2-carboxamides as carbonic anhydrase inhibitors

• 主要な著者: Pavitra S. Thacker (著者), Pirpasha Shaikh (著者), Andrea Angeli (著者), Mohammed Arifuddin (著者), Claudiu T. Supuran (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

A series of novel 8-substituted-N-(4-sulfamoylphenyl)quinoline-2-carboxamides was synthesised by the reaction of 8-hydroxy-N-(4-sulfamoylphenyl) quinoline-2-carboxamide with alkyl and benzyl halides. The compounds were assayed for carbonic anhydrase (CA) inhibitory activity against four hCA isoforms...