Quillaja saponin mitigates methotrexate-provoked renal injury; insight into Nrf-2/Keap-1 pathway modulation with suppression of oxidative stress and inflammation

• Hoofdauteurs: Mustafa Ahmed Abdel-Reheim (Auteur), Merhan E. Ali (Auteur), Ahmed Gaafar A. Gaafar (Auteur), Ahmed Amine Ashour (Auteur)
• Formaat: Boek
• Gepubliceerd in: BMC, 2024-04-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract Background Methotrexate (MTX) is an antineoplastic/immunosuppressive drug, whose clinical use is impeded owing to its serious adverse effects; one of which is acute kidney injury (AKI). Most of MTX complications emerged from the provoked pro-oxidant-, pro-inflammatory- and pro-apoptotic eff...