Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness.

• Main Authors: Els Torreele (Author), Bernadette Bourdin Trunz (Author), David Tweats (Author), Marcel Kaiser (Author), Reto Brun (Author), Guy Mazué (Author), Michael A Bray (Author), Bernard Pécoul (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human African trypanosomiasis (HAT), also known as sleeping sickness, is a fatal parasitic disease caused by trypanosomes. Current treatment options for HAT are scarce, toxic, no longer effective, or very difficult to administer, in particular for the advanced, fatal stage of the disease (stage 2, c...