Suppression of hepatic ChREBP⍺-CYP2C50 axis-driven fatty acid oxidation sensitizes mice to diet-induced MASLD/MASH

• Main Authors: Deqiang Zhang (Author), Yuee Zhao (Author), Gary Zhang (Author), Daniel Lank (Author), Sarah Cooke (Author), Sujuan Wang (Author), Alli Nuotio-Antar (Author), Xin Tong (Author), Lei Yin (Author)
• Format: Book
• Published: Elsevier, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Compromised hepatic fatty acid oxidation (FAO) has been observed in human MASH patients and animal models of MASLD/MASH. It remains poorly understood how and when the hepatic FAO pathway is suppressed during the progression of MASLD towards MASH. Hepatic ChREBP⍺ is a classical lipogenic...