Formulation of Liver-Specific PLGA-DY-635 Nanoparticles Loaded with the Protein Kinase C Inhibitor Bisindolylmaleimide I

• Main Authors: Blerina Shkodra (Author), Adrian T. Press (Author), Antje Vollrath (Author), Ivo Nischang (Author), Stephanie Schubert (Author), Stephanie Hoeppener (Author), Dorothee Haas (Author), Christoph Enzensperger (Author), Marc Lehmann (Author), Petra Babic (Author), Kay Jovana Benecke (Author), Anja Traeger (Author), Michael Bauer (Author), Ulrich S. Schubert (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2020-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Bisindolylmaleimide I (BIM-I) is a competitive pan protein kinase C inhibitor with anti-inflammatory and anti-metastatic properties, suggested to treat inflammatory diseases and various cancer entities. However, despite its therapeutic potential, BIM-I has two major drawbacks, i.e., it has a poor wa...