Exploring the kinetic selectivity of drugs targeting the β1‐adrenoceptor

• প্রধান লেখক: David A. Sykes (লেখক), Mireia Jiménez‐Rosés (লেখক), John Reilly (লেখক), Robin A. Fairhurst (লেখক), Steven J. Charlton (লেখক), Dmitry B. Veprintsev (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Wiley, 2022-08-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract In this study, we report the β1‐adrenoceptor binding kinetics of several clinically relevant β1/2‐adrenoceptor (β1/2AR) agonists and antagonists. [3H]‐DHA was used to label CHO‐β1AR for binding studies. The kinetics of ligand binding was assessed using a competition association binding meth...