The Novel Artemisinin Dimer Isoniazide ELI-XXIII-98-2 Induces c-MYC Inhibition, DNA Damage, and Autophagy in Leukemia Cells

• Main Authors: Mohamed Elbadawi (Author), Joelle C. Boulos (Author), Mona Dawood (Author), Min Zhou (Author), Waseem Gul (Author), Mahmoud A. ElSohly (Author), Sabine M. Klauck (Author), Thomas Efferth (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The proto-oncogenic transcription factor c-MYC plays a pivotal role in the development of tumorigenesis, cellular proliferation, and the control of cell death. Its expression is frequently altered in many cancer types, including hematological malignancies such as leukemia. The dimer isoniazide ELI-X...