Inclusion complex of amiodarone hydrochloride with cyclodextrins: preparation, characterization and dissolution rate evaluation

• Главные авторы: Alexandre Machado Rubim (Автор), Jaqueline Bandeira Rubenick (Автор), Marcela Maurer (Автор), Luciane Varini Laporta (Автор), Clarice Madalena Bueno Rolim (Автор)
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• Опубликовано: Universidade de São Paulo, 2017-06-01T00:00:00Z.
• Предметы: article
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ABSTRACT This study aimed to improve the water solubility of amiodarone hydrochloride (AMH) via inclusion complexes with β-cyclodextrin, methyl-β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin. Inclusion complexes were developed by physical mixture, coevaporation, spray-drying and freeze-drying. So...