Inclusion complex of amiodarone hydrochloride with cyclodextrins: preparation, characterization and dissolution rate evaluation

ABSTRACT This study aimed to improve the water solubility of amiodarone hydrochloride (AMH) via inclusion complexes with β-cyclodextrin, methyl-β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin. Inclusion complexes were developed by physical mixture, coevaporation, spray-drying and freeze-drying. So...

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Main Authors: Alexandre Machado Rubim (Author), Jaqueline Bandeira Rubenick (Author), Marcela Maurer (Author), Luciane Varini Laporta (Author), Clarice Madalena Bueno Rolim (Author)
Format: Book
Published: Universidade de São Paulo, 2017-06-01T00:00:00Z.
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