Identification of Oleanolic Acid as Allosteric Agonist of Integrin αM by Combination of In Silico Modeling and In Vitro Analysis

• Autores principales: Lu Jin (Autor), Xiaoyu Han (Autor), Xinlei Zhang (Autor), Zhimin Zhao (Autor), Judith Ulrich (Autor), Tatiana Syrovets (Autor), Thomas Simmet (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Oleanolic acid is a widely distributed natural product, which possesses promising antitumor, antiviral, antihyperlipidemic, and anti-inflammatory activities. A heterodimeric complex formed by integrin αM (CD11b) and integrin β2 (CD18) is highly expressed on monocytes and macrophages. In the current...