Urotensin II Induces ER Stress and EMT and Increase Extracellular Matrix Production in Renal Tubular Epithelial Cell in Early Diabetic Mice

• Main Authors: Xin-Xin Pang (Author), Qiong Bai (Author), Fei Wu (Author), Guan-Jong Chen (Author), Ai-Hua Zhang (Author), Chao-Shu Tang (Author)
• Format: Book
• Published: Karger Publishers, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Urotensin II (UII) and its receptor are highly expressed in the kidney tissue of patients with diabetic nephropathy (DN). The aim of this study is to examine the roles of UII in the induction of endoplasmic reticulum stress (ER stress) and Epithelial-mesenchymal transition (EMT) in...