Tissue Specific Modulation of cyp2c and cyp3a mRNA Levels and Activities by Diet-Induced Obesity in Mice: The Impact of Type 2 Diabetes on Drug Metabolizing Enzymes in Liver and Extra-Hepatic Tissues

• Главные авторы: Sarah Maximos (Автор), Michel Chamoun (Автор), Sophie Gravel (Автор), Jacques Turgeon (Автор), Veronique Michaud (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2017-09-01T00:00:00Z.
• Предметы: article
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Various diseases such as type 2 diabetes (T2D) may alter drug clearance. The objective of this study was to evaluate the effects of T2D on CYP450 expressions and activities using high-fat diet (HFD) as a model of obesity-dependent diabetes in C57BL6 mice. The cyp450 mRNA expression levels for 15 dif...