The Effect of Capsule-in-Capsule Combinations on In Vivo Disintegration in Human Volunteers: A Combined Imaging and Salivary Tracer Study

• Main Authors: Adrian Rump (Author), Franziska N. Weiss (Author), Louisa Schulz (Author), Marie-Luise Kromrey (Author), Eberhard Scheuch (Author), Mladen V. Tzvetkov (Author), Tyler White (Author), Shane Durkee (Author), Kevin W. Judge (Author), Vincent Jannin (Author), Aouatef Bellamine (Author), Werner Weitschies (Author), Michael Grimm (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Controlling the time point and site of the release of active ingredients within the gastrointestinal tract after administration of oral delivery systems is still a challenge. In this study, the effect of the combination of small capsules (size 3) and large capsules (size 00) on the disintegration si...