Bilateral Paraventricular Nucleus Upregulation of Extracellular Superoxide Dismutase Decreases Blood Pressure by Regulation of the NLRP3 and Neurotransmitters in Salt-Induced Hypertensive Rats

• Main Authors: Qing Su (Author), Xiao-Jing Yu (Author), Xiao-Min Wang (Author), Hong-Bao Li (Author), Ying Li (Author), Juan Bai (Author), Jie Qi (Author), Nianping Zhang (Author), Kai-Li Liu (Author), Yan Zhang (Author), Guo-Qing Zhu (Author), Yu-Ming Kang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims: Long-term salt diet induces the oxidative stress in the paraventricular nucleus (PVN) and increases the blood pressure. Extracellular superoxide dismutase (Ec-SOD) is a unique antioxidant enzyme that exists in extracellular space and plays an essential role in scavenging excessive reactive oxy...