Discovery of Small Molecule NSC290956 as a Therapeutic Agent for KRas Mutant Non-Small-Cell Lung Cancer

HRas-GTP has a transient intermediate state with a "non-signaling open conformation" in GTP hydrolysis and nucleotide exchange. Due to the same hydrolysis process and the structural homology, it can be speculated that the active KRas adopts the same characteristics with the "open conf...

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Main Authors: Jiaxin Zhang (Author), Zuojia Liu (Author), Wenjing Zhao (Author), Xunzhe Yin (Author), Xiliang Zheng (Author), Chuanbo Liu (Author), Jin Wang (Author), Erkang Wang (Author)
Format: Book
Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
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3rd Floor Main Library

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