Structure-activity relationship of pyrazol-4-yl-pyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M4

• Main Authors: Ahmed Haider (Author), Xiaoyun Deng (Author), Olivia Mastromihalis (Author), Stefanie K. Pfister (Author), Troels E. Jeppesen (Author), Zhiwei Xiao (Author), Vi Pham (Author), Shaofa Sun (Author), Jian Rong (Author), Chunyu Zhao (Author), Jiahui Chen (Author), Yinlong Li (Author), Theresa R. Connors (Author), April T. Davenport (Author), James B. Daunais (Author), Vahid Hosseini (Author), Wenqing Ran (Author), Arthur Christopoulos (Author), Lu Wang (Author), Celine Valant (Author), Steven H. Liang (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is an accumulating body of evidence implicating the muscarinic acetylcholine receptor 4 (M4) in schizophrenia and dementia with Lewy bodies, however, a clinically validated M4 positron emission tomography (PET) radioligand is currently lacking. As such, the aim of this study was to develop a s...