Structure-activity relationship of pyrazol-4-yl-pyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M4

• Главные авторы: Ahmed Haider (Автор), Xiaoyun Deng (Автор), Olivia Mastromihalis (Автор), Stefanie K. Pfister (Автор), Troels E. Jeppesen (Автор), Zhiwei Xiao (Автор), Vi Pham (Автор), Shaofa Sun (Автор), Jian Rong (Автор), Chunyu Zhao (Автор), Jiahui Chen (Автор), Yinlong Li (Автор), Theresa R. Connors (Автор), April T. Davenport (Автор), James B. Daunais (Автор), Vahid Hosseini (Автор), Wenqing Ran (Автор), Arthur Christopoulos (Автор), Lu Wang (Автор), Celine Valant (Автор), Steven H. Liang (Автор)
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• Опубликовано: Elsevier, 2023-01-01T00:00:00Z.
• Предметы: article
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There is an accumulating body of evidence implicating the muscarinic acetylcholine receptor 4 (M4) in schizophrenia and dementia with Lewy bodies, however, a clinically validated M4 positron emission tomography (PET) radioligand is currently lacking. As such, the aim of this study was to develop a s...