OTS964, a TOPK Inhibitor, Is Susceptible to ABCG2-Mediated Drug Resistance

• Main Authors: Yuqi Yang (Author), Zhuo-Xun Wu (Author), Jing-Quan Wang (Author), Qiu-Xu Teng (Author), Zi-Ning Lei (Author), Sabrina Lusvarghi (Author), Suresh V. Ambudkar (Author), Zhe-Sheng Chen (Author), Dong-Hua Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

OTS964 is a potent T-LAK cell-originated protein kinase (TOPK) inhibitor. Herein, we investigated the interaction of OTS964 and multidrug resistance (MDR)-associated ATP-binding cassette sub-family G member 2 (ABCG2). The cell viability assay indicated that the effect of OTS964 is limited in cancer...