Engineering of a Fully Human Anti-MUC-16 Antibody and Evaluation as a PET Imaging Agent

• Main Authors: Hanan Babeker (Author), Jessica Pougoue Ketchemen (Author), Arunkumar Annan Sudarsan (Author), Samitha Andrahennadi (Author), Anjong Florence Tikum (Author), Anand Krishnan Nambisan (Author), Humphrey Fonge (Author), Maruti Uppalapati (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antibodies that recognize cancer biomarkers, such as MUC16, can be used as vehicles to deliver contrast agents (imaging) or cytotoxic payloads (therapy) to the site of tumors. MUC16 is overexpressed in 80% of epithelial ovarian cancer (EOC) and 65% of pancreatic ductal adenocarcinomas (PDAC), where...