Modeling the effect of ascites-induced compression on ovarian cancer multicellular aggregates

• Main Authors: Yuliya Klymenko (Author), Rebecca B. Wates (Author), Holly Weiss-Bilka (Author), Rachel Lombard (Author), Yueying Liu (Author), Leigh Campbell (Author), Oleg Kim (Author), Diane Wagner (Author), Matthew J. Ravosa (Author), M. Sharon Stack (Author)
• Format: Book
• Published: The Company of Biologists, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. EOC dissemination is predominantly via direct extension of cells and multicellular aggregates (MCAs) into the peritoneal cavity, which adhere to and induce retraction of peritoneal mesothelium and proliferate in the submeso...