Matrix stiffness mechanosensing modulates the expression and distribution of transcription factors in Schwann cells

• Main Authors: Gonzalo Rosso (Author), Daniel Wehner (Author), Christine Schweitzer (Author), Stephanie Möllmert (Author), Elisabeth Sock (Author), Jochen Guck (Author), Victor Shahin (Author)
• Format: Book
• Published: Wiley, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract After peripheral nerve injury, mature Schwann cells (SCs) de‐differentiate and undergo cell reprogramming to convert into a specialized cell repair phenotype that promotes nerve regeneration. Reprogramming of SCs into the repair phenotype is tightly controlled at the genome level and includ...