Interleukin-7 receptor blockade suppresses adaptive and innate inflammatory responses in experimental colitis

• Main Authors: Willis Cynthia R (Author), Seamons Audrey (Author), Maxwell Joe (Author), Treuting Piper M (Author), Nelson Laurel (Author), Chen Guang (Author), Phelps Susan (Author), Smith Carole L (Author), Brabb Thea (Author), Iritani Brian M (Author), Maggio-Price Lillian (Author)
• Format: Book
• Published: BMC, 2012-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Interleukin-7 (IL-7) acts primarily on T cells to promote their differentiation, survival, and homeostasis. Under disease conditions, IL-7 mediates inflammation through several mechanisms and cell types. In humans, IL-7 and its recep...