Inhibition of P-glycoprotein and multidrug resistance-associated protein 2 regulates the hepatobiliary excretion and plasma exposure of thienorphine and its glucuronide conjugate

• Autores principales: Ling-Lei Kong (Autor), Guo-Lin Shen (Autor), Zhi-Yuan Wang (Autor), Xiao-Mei Zhuang (Autor), Wei-Bin Xiao (Autor), Mei Yuan (Autor), Ze-Hui Gong (Autor), Hua Li (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2016-08-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Thienorphine (TNP) is a novel partial opioid agonist that has completed phase II clinical evaluation as a promising drug candidate for the treatment of opioid dependence. Previous studies have shown that TNP and its glucuronide conjugate (TNP-G) undergo significant bile excretion. The purpose of thi...