Inhibition of P-glycoprotein and multidrug resistance-associated protein 2 regulates the hepatobiliary excretion and plasma exposure of thienorphine and its glucuronide conjugate

Thienorphine (TNP) is a novel partial opioid agonist that has completed phase II clinical evaluation as a promising drug candidate for the treatment of opioid dependence. Previous studies have shown that TNP and its glucuronide conjugate (TNP-G) undergo significant bile excretion. The purpose of thi...

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में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Ling-Lei Kong (लेखक), Guo-Lin Shen (लेखक), Zhi-Yuan Wang (लेखक), Xiao-Mei Zhuang (लेखक), Wei-Bin Xiao (लेखक), Mei Yuan (लेखक), Ze-Hui Gong (लेखक), Hua Li (लेखक)
स्वरूप: पुस्तक
प्रकाशित: Frontiers Media S.A., 2016-08-01T00:00:00Z.
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