Inhibition of P-glycoprotein and multidrug resistance-associated protein 2 regulates the hepatobiliary excretion and plasma exposure of thienorphine and its glucuronide conjugate

Thienorphine (TNP) is a novel partial opioid agonist that has completed phase II clinical evaluation as a promising drug candidate for the treatment of opioid dependence. Previous studies have shown that TNP and its glucuronide conjugate (TNP-G) undergo significant bile excretion. The purpose of thi...

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Asıl Yazarlar: Ling-Lei Kong (Yazar), Guo-Lin Shen (Yazar), Zhi-Yuan Wang (Yazar), Xiao-Mei Zhuang (Yazar), Wei-Bin Xiao (Yazar), Mei Yuan (Yazar), Ze-Hui Gong (Yazar), Hua Li (Yazar)
Materyal Türü: Kitap
Baskı/Yayın Bilgisi: Frontiers Media S.A., 2016-08-01T00:00:00Z.
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