Inhibition of P-glycoprotein and multidrug resistance-associated protein 2 regulates the hepatobiliary excretion and plasma exposure of thienorphine and its glucuronide conjugate

Thienorphine (TNP) is a novel partial opioid agonist that has completed phase II clinical evaluation as a promising drug candidate for the treatment of opioid dependence. Previous studies have shown that TNP and its glucuronide conjugate (TNP-G) undergo significant bile excretion. The purpose of thi...

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Main Authors: Ling-Lei Kong (Author), Guo-Lin Shen (Author), Zhi-Yuan Wang (Author), Xiao-Mei Zhuang (Author), Wei-Bin Xiao (Author), Mei Yuan (Author), Ze-Hui Gong (Author), Hua Li (Author)
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Publicado em: Frontiers Media S.A., 2016-08-01T00:00:00Z.
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