Discovery of Dual TRPA1 and TRPV1 Antagonists as Novel Therapeutic Agents for Pain

• Main Authors: Nayeon Do (Author), Dongxu Zuo (Author), Miri Kim (Author), Minseok Kim (Author), Hee-Jin Ha (Author), Peter M. Blumberg (Author), Jihyae Ann (Author), Sun Wook Hwang (Author), Jeewoo Lee (Author)
• Format: Book
• Published: MDPI AG, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pain management remains a major challenge in medicine, highlighting the need for the development of new therapeutic agents. The transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) are ion channels that play key roles in pain perception. Targeting both TRPA1 and TRPV1 simultaneousl...