Association of TGFβ1, TNFα, CCR2 and CCR5 gene polymorphisms in type-2 diabetes and renal insufficiency among Asian Indians

• Main Authors: Gupta Arvind (Author), Ammini AC (Author), Kumar KM Prasanna (Author), Tiwari Arun K (Author), Prasad Pushplata (Author), Gupta Rajeev (Author), Thelma BK (Author)
• Format: Book
• Published: BMC, 2007-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Cytokines play an important role in the development of diabetic chronic renal insufficiency (CRI). Transforming growth factor β1 (TGF β1) induces renal hypertrophy and fibrosis, and cytokines like tumor necrosis factor-alpha (TNFα),...