Repurposing Mebendazole as a Replacement for Vincristine for the Treatment of Brain Tumors

• Main Authors: Michelle De Witt (Author), Alexander Gamble (Author), Derek Hanson (Author), Daniel Markowitz (Author), Caitlin Powell (Author), Saleh Al Dimassi (Author), Mark Atlas (Author), John Boockvar (Author), Rosamaria Ruggieri (Author), Marc Symons (Author)
• Format: Book
• Published: BMC, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The microtubule inhibitor vincristine is currently used to treat a variety of brain tumors, including low-grade glioma and anaplastic oligodendroglioma. Vincristine, however, does not penetrate well into brain tumor tissue, and moreover, it displays dose-limiting toxicities, including perip...