High frequency of the IVS2-2A>G DNA sequence variation in <it>SLC26A5</it>, encoding the cochlear motor protein prestin, precludes its involvement in hereditary hearing loss

• Main Authors: Pereira Fred A (Author), Oghalai John S (Author), Xia Anping (Author), Tang Hsiao-Yuan (Author), Alford Raye L (Author)
• Format: Book
• Published: BMC, 2005-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Cochlear outer hair cells change their length in response to variations in membrane potential. This capability, called electromotility, is believed to enable the sensitivity and frequency selectivity of the mammalian cochlea. Prestin...