Pertuzumab Increases 17-AAG-Induced Degradation of ErbB2, and This Effect Is Further Increased by Combining Pertuzumab with Trastuzumab

• Main Authors: Juliana Bentes Hughes (Author), Marianne Skeie Rødland (Author), Max Hasmann (Author), Inger Helene Madshus (Author), Espen Stang (Author)
• Format: Book
• Published: MDPI AG, 2012-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ErbB2 is an important oncogenic protein involved in carcinogenesis of, among others, breast, gastric, and ovarian carcinoma. Over-expression of ErbB2 is found in almost 20% of breast cancers, and this results in proliferative and anti-apoptotic signalling. ErbB2 is therefore an important treatment t...