A Dry Powder Platform for Nose-to-Brain Delivery of Dexamethasone: Formulation Development and Nasal Deposition Studies

• Main Authors: Laura Nižić Nodilo (Author), Ivo Ugrina (Author), Drago Špoljarić (Author), Daniela Amidžić Klarić (Author), Cvijeta Jakobušić Brala (Author), Mirna Perkušić (Author), Ivan Pepić (Author), Jasmina Lovrić (Author), Vesna Saršon (Author), Maša Safundžić Kučuk (Author), Dijana Zadravec (Author), Livije Kalogjera (Author), Anita Hafner (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nasal route of administration offers a unique opportunity of brain targeted drug delivery via olfactory and trigeminal pathway, providing effective CNS concentrations at lower doses and lower risk for adverse reactions compared to systemic drug administration. Therefore, it has been recently propose...