A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats

• Main Authors: Pan Meng (Author), Xi Zhang (Author), Tong-tong Liu (Author), Jian Liu (Author), Yan Luo (Author), Ming-xia Xie (Author), Hui Yang (Author), Rui Fang (Author), Dong-wei Guo (Author), Zi-yan Zhong (Author), Yu-hong Wang (Author), Jin-Wen Ge (Author)
• Format: Book
• Published: BMC, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Depression is a neuropsychiatric disease resulting from deteriorations of molecular networks and synaptic injury induced by stress. Traditional Chinese formula Xiaoyaosan (XYS) exert antidepressant effect, which was demonstrated by a great many of clinical and basic investigation...